Activation of Gαq sequesters specific transcripts into Ago2 particles
نویسندگان
چکیده
The Gαq/phospholipase Cβ1 (PLCβ1) signaling system mediates calcium responses from hormones and neurotransmitters. While PLCβ1 functions on the plasma membrane, there is an atypical cytosolic population that binds Ago2 other proteins associated with stress granules preventing their aggregation. Activation of Gαq relocalizes to releasing bound proteins, promoting formation granules. Here, we have characterized activation in differentiated PC12 cells, which a robust Gαq/PLCβ1 system.
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2022
ISSN: ['0006-3495', '1542-0086']
DOI: https://doi.org/10.1016/j.bpj.2021.11.1706